What a test can show
Genotyping and/or phenotyping under a clinical protocol.
Pharmacogenomics
TPMTThiopurines
Reduced TPMT activity increases risk of severe myelosuppression at standard thiopurine doses.
RELATIONSHIP VALIDITYCPIC clinical guideline
ACTIONABILITYHigh in thiopurine therapy
SOURCE CHECKLinks and claim boundaries are editorially checked; external expert review is stated only with named disclosure
Practical meaning
A result may alter starting dose, but blood monitoring remains essential.
Where knowledge ends
It does not replace NUDT15 assessment, interaction review or clinical monitoring.
SOURCES AND VERSION
Verifiable, not ‘trust us’.
Updated: 14 August 2026. Any clinical interpretation requires the exact variant, testing method, family information and medical context.