What a test can show
Validated genotype/phenotype before therapy under the local clinical protocol.
Pharmacogenomics
DPYDFluoropyrimidines
Reduced DPD activity can increase risk of severe fluoropyrimidine toxicity.
RELATIONSHIP VALIDITYCPIC clinical guideline
ACTIONABILITYHigh in the prescribing context
SOURCE CHECKLinks and claim boundaries are editorially checked; external expert review is stated only with named disclosure
Practical meaning
A result may influence clinician-led starting dose or treatment choice.
Where knowledge ends
A common-variant panel does not detect every cause of DPD deficiency.
SOURCES AND VERSION
Verifiable, not ‘trust us’.
Updated: 14 August 2026. Any clinical interpretation requires the exact variant, testing method, family information and medical context.