What a test can show
Comprehensive clinical CDH1 analysis; indications depend on personal/family history and tumour histology.
Monogenic conditions
CDH1Hereditary diffuse gastric cancer
Pathogenic germline variants are associated with diffuse gastric and lobular breast cancer risks.
RELATIONSHIP VALIDITYHigh in the appropriate phenotype
ACTIONABILITYHigh, with complex multidisciplinary decisions
SOURCE CHECKLinks and claim boundaries are editorially checked; external expert review is stated only with named disclosure
Practical meaning
Preventive decisions must not be based on a VUS or made without histology and family-context confirmation.
Where knowledge ends
Not every gastric cancer or CDH1 variant belongs to this syndrome.
SOURCES AND VERSION
Verifiable, not ‘trust us’.
Updated: 14 August 2026. Any clinical interpretation requires the exact variant, testing method, family information and medical context.