What a test can show
Clinical sequencing and large rearrangement analysis; the variant must be classified.
Monogenic conditions
BRCA1Hereditary cancer predisposition
Pathogenic variants increase risks of several cancers, especially breast and ovarian cancer.
RELATIONSHIP VALIDITYHigh: established causality
ACTIONABILITYHigh for a confirmed pathogenic variant
SOURCE CHECKLinks and claim boundaries are editorially checked; external expert review is stated only with named disclosure
Practical meaning
A confirmed result may change surveillance, prevention decisions and family testing.
Where knowledge ends
A positive result does not make cancer inevitable; a negative result does not erase population or family risk.
SOURCES AND VERSION
Verifiable, not ‘trust us’.
Updated: 14 August 2026. Any clinical interpretation requires the exact variant, testing method, family information and medical context.